Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281190 | 0.98 | NAMPT (0.42) | NAMPTACHEDRD4CHRM4RAB9A | |
| SCHEMBL7273026 | 0.92 | NAMPT (0.40) | NAMPTDRD4RAB9ASLC6A2SLC6A4 | |
| SCHEMBL7274972 | 0.90 | NAMPT (0.40) | NAMPTDRD4RAB9ASLC6A2SLC6A4 | |
| SCHEMBL7281022 | 0.88 | CHRM4 (0.42) | NAMPTDRD4CHRM4RAB9ASLC6A2 | |
| Hydrochloric Acid SCHEMBL7283406 | 0.87 | ACHE (0.41) | NAMPTACHEDRD4CHRM4RAB9A | |
| Hydrochloric Acid SCHEMBL7281722 | 0.85 | DRD4 (0.40) | ACHEDRD4CHRM4RAB9ASLC6A2 | |
| SCHEMBL7284718 | 0.84 | HTR1A (0.42) | NAMPTDRD4DRD2DRD3 | |
| SCHEMBL7274708 | 0.82 | CHRM4 (0.42) | NAMPTDRD4CHRM4RAB9ACCR3 | |
| SCHEMBL7275479 | 0.82 | NAMPT (0.52) | NAMPTDRD4CHRM4OPRM1DRD2 | |
| SCHEMBL7275082 | 0.82 | CHRM4 (0.38) | NAMPTCHRM4RAB9ALMNAOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |