Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 5/20 | 0.66 |
| ▸ | ACE | P12821 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | FKBP1A | P62942 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PRCP | P42785 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11764594 | 0.89 | PREP (0.71) | PREPACEALDH1A1FKBP1AKMT2A | |
| SCHEMBL2228388 | 0.89 | PREP (0.71) | PREPACEALDH1A1FKBP1AKMT2A | |
| SCHEMBL2082597 | 0.88 | PREP (0.69) | PREPACEALDH1A1FKBP1AKMT2A | |
| SCHEMBL9518270 | 0.87 | PREP (0.68) | PREPACEALDH1A1FKBP1AKMT2A | |
| SCHEMBL11033242 | 0.87 | PREP (0.68) | PREPACEALDH1A1FKBP1AKMT2A | |
| SCHEMBL9464405 | 0.86 | PREP (0.67) | PREPACEALDH1A1FKBP1ACYP3A4 | |
| SCHEMBL11760983 | 0.86 | PREP (0.67) | PREPACEALDH1A1FKBP1AKMT2A | |
| SCHEMBL18620837 | 0.86 | PREP (0.67) | PREPACEALDH1A1FKBP1ACYP3A4 | |
| SCHEMBL11761001 | 0.86 | PREP (0.67) | PREPACEALDH1A1FKBP1AKMT2A | |
| SCHEMBL13471059 | 0.86 | PREP (0.67) | PREPACEALDH1A1FKBP1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-60172929-A | — | — | None | — | — | JP | disclosed |
| EP-0965585-A1 | Anti-amnesic thiazolidine derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-12-22 | — | — | EP | disclosed |
| EP-0537802-B1 | N-acylpyrrolidines, process for their preparation and their use for prevention and/or treatment of amnesia | ONO PHARMACEUTICAL CO (JP) | 1999-08-25 | — | — | EP | disclosed |
| EP-0461677-B1 | Novel thiazolidine derivatives | ONO PHARMACEUTICAL CO (JP) | 1997-04-16 | — | — | EP | disclosed |
| US-5545657-A | 1-ALKYLOYLPYRROLIDIN-2-YLOXOALKANOIC ACIDS AND DERIVATIVES; ANTIAMNESIA AGENTS; INHIBITORS OF PROLYL ENDOPEPTIDASE; SUPPRESSION OF NEUROTRANSMITTER METABOLISM | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-13 | — | — | US | disclosed |
| US-5411976-A | New thiazolidine derivatives, process for preparing same and anti-amnestic composition containing same | KABUSHIKI KAISHA YAKULT NONSHA (JP) | 1995-05-02 | — | — | US | disclosed |
| US-5411974-A | Thiazoline derivatives, treatment of amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-05-02 | — | — | US | disclosed |
| US-5401760-A | Thiazoline derivative for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-03-28 | — | — | US | disclosed |
| EP-0345428-B1 | Anti-amnesic pyrrolidine derivatives | ONO PHARMACEUTICAL CO (JP) | 1995-01-18 | — | — | EP | disclosed |
| US-5340832-A | Prolinal derivatives useful for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0154353-B1 | AN ANTI-AMNESTIC AGENT | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1989-11-15 | — | — | EP | disclosed |
| US-4880827-A | Pyrrolidine derivatives having inhibitory action for proline specific endopepidase | SUMITOMO PHARMACEUTICALS COMPANY, LTD. (JP) | 1989-11-14 | — | — | US | disclosed |
| US-4857537-A | PREVENTING AMNESIA | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| EP-0280956-A1 | Thiazolidine derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-09-07 | — | — | EP | disclosed |
| EP-0277588-A1 | Prolinal derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-08-10 | — | — | EP | disclosed |
| EP-0275482-A2 | Proline derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-07-27 | — | — | EP | disclosed |
| EP-0268190-A1 | Prolinal derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-05-25 | — | — | EP | disclosed |
| US-4687778-A | Anti-amnestic agent | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1987-08-18 | — | — | US | disclosed |
| EP-0154353-A2 | An anti-amnestic agent | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1985-09-11 | — | — | EP | disclosed |
| JP-S60172929-A | AGENT FOR ALLEVIATING AMNESIA | YAKULT HONSHA CO LTD | 1985-09-06 | — | — | JP | disclosed |