Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 4/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272937 | 0.87 | NPC1 (0.56) | POLBKCNH2NPC1RAB9A | |
| SCHEMBL7293750 | 0.85 | TACR1 (0.46) | TACR1 | |
| SCHEMBL7275454 | 0.84 | CCR1 (0.45) | POLBKCNH2NPC1RAB9A | |
| SCHEMBL7267087 | 0.83 | ALDH1A1 (0.48) | SIGMAR1 | |
| SCHEMBL7271874 | 0.83 | CCR1 (0.50) | RAB9A | |
| SCHEMBL7318507 | 0.83 | NPC1 (0.40) | SIGMAR1SLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL7284049 | 0.82 | TACR1 (0.44) | TACR1 | |
| SCHEMBL7265331 | 0.82 | KMT2A (0.46) | SIGMAR1TACR1UTS2R | |
| SCHEMBL7279739 | 0.81 | UTS2R (0.43) | POLBUTS2RCXCR4 | |
| SCHEMBL8994513 | 0.81 | TACR1 (0.43) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5340832-A | Prolinal derivatives useful for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-08-23 | — | — | US | claimed |
| EP-0268190-B1 | PROLINAL DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-06-16 | — | — | EP | claimed |
| EP-0268190-A1 | Prolinal derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-05-25 | — | — | EP | claimed |
| US-5340832-A | Prolinal derivatives useful for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| US-4956380-A | COGNITION ACTIVATORS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1990-09-11 | — | — | US | disclosed |