Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 4/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293796 | 0.85 | KMT2A (0.45) | KMT2AMEN1SIGMAR1METAP2DPP4 | |
| SCHEMBL7322701 | 0.83 | METAP2 (0.40) | KMT2AMEN1SIGMAR1METAP2METAP1 | |
| SCHEMBL7272937 | 0.83 | NPC1 (0.56) | KMT2APREP | |
| SCHEMBL7294217 | 0.82 | METAP2 (0.46) | KMT2AMEN1SIGMAR1METAP2DPP4 | |
| SCHEMBL7272889 | 0.82 | SIGMAR1 (0.43) | SIGMAR1UTS2RTACR1 | |
| SCHEMBL7284471 | 0.81 | DPP4 (0.47) | KMT2AMEN1DPP4UTS2RPREP | |
| SCHEMBL8994540 | 0.81 | KDM4E (0.46) | KMT2AMEN1SIGMAR1METAP2DPP4 | |
| SCHEMBL770128 | 0.80 | SIGMAR1 (0.48) | KMT2AMEN1SIGMAR1METAP2DPP4 | |
| SCHEMBL771335 | 0.80 | SIGMAR1 (0.48) | KMT2AMEN1SIGMAR1METAP2DPP4 | |
| SCHEMBL7265407 | 0.79 | DPP4 (0.53) | KMT2AMEN1DPP4PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5340832-A | Prolinal derivatives useful for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-08-23 | — | — | US | claimed |
| EP-0268190-B1 | PROLINAL DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-06-16 | — | — | EP | claimed |
| EP-0268190-A1 | Prolinal derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-05-25 | — | — | EP | claimed |
| US-5340832-A | Prolinal derivatives useful for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |