Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.40 |
| ▸ | HTR7 | P34969 | 6/20 | 0.40 |
| ▸ | HTR6 | P50406 | 6/20 | 0.40 |
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | ATF1 | P18846 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273354 | 0.87 | HRH4 (0.50) | DRD2HTR7HTR6HTR2AHRH4 | |
| SCHEMBL7271093 | 0.84 | LMNA (0.39) | DRD2HTR7HTR6HTR2AHRH4 | |
| SCHEMBL7282498 | 0.82 | HRH3 (0.39) | DRD2HTR7HTR6HTR2AHRH4 | |
| SCHEMBL7282241 | 0.82 | MTOR (0.48) | PIK3CA | |
| SCHEMBL7282299 | 0.78 | LMNA (0.39) | DRD2HTR7HTR6HTR2APTPN11 | |
| SCHEMBL136405 | 0.71 | KCNK2 (0.61) | DRD2HTR7HTR6HTR2AHRH4 | |
| SCHEMBL7272544 | 0.71 | ALDH1A1 (0.41) | HTR2A | |
| SCHEMBL6049488 | 0.69 | HRH4 (0.54) | DRD2HTR7HTR6HTR2AHRH4 | |
| SCHEMBL8842601 | 0.67 | PIK3CA (0.46) | PIK3CAKCNK2SCN2A | |
| SCHEMBL5070744 | 0.66 | KCNK2 (0.54) | DRD2HTR7HTR6HTR2AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679645-A1 | Pharmacologically active CNS pyridmidin compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-11-02 | — | — | EP | claimed |
| EP-0459819-A2 | Pharmacologically active CNS compound | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-04 | — | — | EP | claimed |
| EP-0679645-A1 | Pharmacologically active CNS pyridmidin compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-11-02 | — | — | EP | disclosed |
| EP-0459819-A2 | Pharmacologically active CNS compound | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |