Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.50 |
| ▸ | HTR3A | P46098 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 7/20 | 0.47 |
| ▸ | DRD2 | P14416 | 6/20 | 0.47 |
| ▸ | HTR7 | P34969 | 6/20 | 0.47 |
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7271093 | 0.87 | LMNA (0.39) | HRH4HTR3AHTR6DRD2HTR7 | |
| SCHEMBL7273080 | 0.87 | DRD2 (0.40) | HRH4HTR3AHTR6DRD2HTR7 | |
| SCHEMBL7282498 | 0.85 | HRH3 (0.39) | HRH4HTR3AHTR6DRD2HTR7 | |
| SCHEMBL7282241 | 0.85 | MTOR (0.48) | — | |
| SCHEMBL136405 | 0.83 | KCNK2 (0.61) | HRH4HTR3AHTR6DRD2HTR7 | |
| SCHEMBL6049488 | 0.82 | HRH4 (0.54) | HRH4HTR3AHTR6DRD2HTR7 | |
| SCHEMBL7282299 | 0.81 | LMNA (0.39) | HTR6DRD2HTR7HTR2AKMT2A | |
| SCHEMBL5070744 | 0.78 | KCNK2 (0.54) | HRH4HTR3AHTR6DRD2HTR7 | |
| SCHEMBL7278942 | 0.76 | HTR6 (0.48) | HRH4HTR3AHTR6DRD2HTR7 | |
| SCHEMBL7272544 | 0.73 | ALDH1A1 (0.41) | HTR2AKMT2ACYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679645-A1 | Pharmacologically active CNS pyridmidin compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-11-02 | — | — | EP | claimed |
| EP-0459819-A2 | Pharmacologically active CNS compound | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-04 | — | — | EP | claimed |
| EP-0679645-A1 | Pharmacologically active CNS pyridmidin compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-11-02 | — | — | EP | disclosed |
| EP-0459819-A2 | Pharmacologically active CNS compound | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |