Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | HTR3A | P46098 | 2/20 | 0.31 |
| ▸ | ICMT | O60725 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PER2 | O15055 | 1/20 | 0.30 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.30 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 2/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | PAK4 | O96013 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297785 | 0.84 | HTR3E (0.42) | KDM4EALDH1A1KDRPTGDR2CMA1 | |
| SCHEMBL7272916 | 0.75 | HTR3E (0.46) | KDM4EALDH1A1MTNR1AMTNR1BHTR3A | |
| Fumaric Acid SCHEMBL7273241 | 0.73 | MEN1 (0.39) | KDM4EALDH1A1KDRPTGDR2EGFR | |
| Maleic Acid SCHEMBL7273221 | 0.73 | MEN1 (0.39) | KDM4EALDH1A1KDRPTGDR2EGFR | |
| Maleic Acid SCHEMBL7273226 | 0.69 | HTR3A (0.42) | KDM4EALDH1A1KDRPTGDR2HTR3A | |
| SCHEMBL7828711 | 0.63 | KDM4E (0.51) | KDM4EALDH1A1PTGDR2CMA1MTNR1A | |
| SCHEMBL21661970 | 0.62 | KDM4E (0.54) | KDM4EALDH1A1KDRCMA1MTNR1A | |
| SCHEMBL27489308 | 0.61 | KDM4E (0.55) | KDM4EALDH1A1KDRCMA1MTNR1A | |
| SCHEMBL8360748 | 0.61 | KDM4E (0.50) | KDM4EALDH1A1KDRCMA1MTNR1A | |
| Maleic Acid SCHEMBL7272831 | 0.60 | HTR3E (0.42) | KDM4EALDH1A1KDRPTGDR2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4808581-A | ANXIOLYTIC, ANTIEMETIC, TREATMENT OF PSYCHOLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 1989-02-28 | — | — | US | disclosed |
| EP-0276163-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1988-07-27 | — | — | EP | disclosed |