Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.33 |
| ▸ | ERBB2 known ✓ | P04626 | 1/20 | 0.33 |
| ▸ | ERBB4 known ✓ | Q15303 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ICMT | O60725 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 4/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7273241 | 1.00 | MEN1 (0.39) | MEN1KMT2AALDH1A1KDM4EICMT | |
| Fumaric Acid SCHEMBL7272833 | 0.82 | HTR3E (0.42) | MEN1KMT2AALDH1A1KDM4EICMT | |
| Maleic Acid SCHEMBL7272831 | 0.82 | HTR3E (0.42) | MEN1KMT2AALDH1A1KDM4EICMT | |
| Maleic Acid SCHEMBL7273226 | 0.79 | HTR3A (0.42) | MEN1KMT2AALDH1A1KDM4EPTGDR2 | |
| SCHEMBL6512748 | 0.74 | AKR1C3 (0.57) | MEN1KMT2AALDH1A1KDM4EICMT | |
| SCHEMBL7273229 | 0.73 | KDM4E (0.36) | MEN1KMT2AALDH1A1KDM4EICMT | |
| Fumaric Acid SCHEMBL7272924 | 0.72 | HTR3A (0.45) | ALDH1A1KDM4EAKR1C3AKR1C2HASPIN | |
| Maleic Acid SCHEMBL7272908 | 0.72 | HTR3A (0.45) | ALDH1A1KDM4EAKR1C3AKR1C2HASPIN | |
| SCHEMBL18508879 | 0.67 | KDM4E (0.58) | MEN1KMT2AALDH1A1KDM4EICMT | |
| Maleic Acid SCHEMBL10540174 | 0.66 | HTR3E (0.66) | MEN1KMT2AALDH1A1KDM4EPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4808581-A | ANXIOLYTIC, ANTIEMETIC, TREATMENT OF PSYCHOLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 1989-02-28 | — | — | US | disclosed |
| EP-0276163-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1988-07-27 | — | — | EP | disclosed |