Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7279487 | 0.90 | AOC3 (0.45) | ALOX5AOC3LMNAMAPTSLC2A1 | |
| SCHEMBL11808022 | 0.83 | ALOX5 (0.53) | ALOX5AOC3PTGS2SLC2A1 | |
| SCHEMBL7274253 | 0.83 | SLC2A1 (0.45) | AOC3LMNAMAPTPTGS2SLC2A1 | |
| SCHEMBL30056339 | 0.83 | AOC3 (0.46) | AOC3LMNAMAPTKMT2AALDH1A1 | |
| SCHEMBL11300908 | 0.83 | AOC3 (0.46) | AOC3LMNAMAPTKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7272112 | 0.81 | ALOX5 (0.44) | ALOX5AOC3SLC2A1 | |
| SCHEMBL27586556 | 0.81 | AOC3 (0.57) | ALOX5AOC3LMNAMAPTKMT2A | |
| SCHEMBL28309045 | 0.81 | ALOX5 (0.54) | ALOX5PTGS2SLC2A1 | |
| SCHEMBL16190956 | 0.81 | ALOX5 (0.43) | ALOX5AOC3PTGS2 | |
| SCHEMBL7282349 | 0.80 | ALOX5 (0.40) | ALOX5AOC3LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4885313-A | 3,4-Dihydroxyphenylethylamine derivatives and their use | FISONS PLC (GB) | 1989-12-05 | — | — | US | disclosed |
| US-4803225-A | Dihydroxy-phenethylamino compounds useful as pharmaceuticals | FISONS, PLC (GB) | 1989-02-07 | — | — | US | disclosed |
| US-4720586-A | Substituted 3,4-dihydroxy-phenylethylamino compounds | FISONS, PLC (GB) | 1988-01-19 | — | — | US | disclosed |
| EP-0142283-A2 | Phenylethylamines, process for their preparation and compositions containing them | FISONS plc (GB) | 1985-05-22 | — | — | EP | disclosed |