Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274726 | 0.93 | SIGMAR1 (0.51) | SIGMAR1CYP3A4HDAC3HDAC1HDAC8 | |
| SCHEMBL7273844 | 0.92 | SIGMAR1 (0.51) | SIGMAR1CYP3A4HDAC3HDAC1HDAC8 | |
| SCHEMBL7274594 | 0.92 | SIGMAR1 (0.51) | SIGMAR1CYP3A4HDAC3HDAC1HDAC8 | |
| SCHEMBL7275131 | 0.92 | SIGMAR1 (0.51) | SIGMAR1CYP3A4HDAC3HDAC1HDAC8 | |
| SCHEMBL7276712 | 0.91 | SIGMAR1 (0.48) | SIGMAR1CYP3A4HDAC3HDAC1HDAC8 | |
| SCHEMBL7283478 | 0.90 | SIGMAR1 (0.54) | SIGMAR1CYP3A4HDAC3HDAC1HDAC8 | |
| SCHEMBL7275050 | 0.90 | SIGMAR1 (0.47) | SIGMAR1CYP3A4HDAC3HDAC1HDAC8 | |
| SCHEMBL7276194 | 0.88 | SIGMAR1 (0.47) | SIGMAR1CYP3A4HDAC3HDAC1HDAC8 | |
| SCHEMBL7280925 | 0.85 | LMNA (0.43) | HDAC3HDAC1HDAC8HDAC6LMNA | |
| SCHEMBL7275906 | 0.85 | SIGMAR1 (0.46) | SIGMAR1CYP3A4HDAC3HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |