Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273664 | 1.00 | DPP4 (0.40) | DPP4RENPPARAKMT2AMEN1 | |
| SCHEMBL7288366 | 0.93 | PPARA (0.38) | DPP4PPARAKMT2AMEN1KDM4E | |
| SCHEMBL7291357 | 0.92 | PPARA (0.38) | DPP4PPARAKMT2AMEN1KDM4E | |
| SCHEMBL7273286 | 0.92 | MAPT (0.41) | PPARAKMT2AMEN1KDM4ENPC1 | |
| SCHEMBL7287672 | 0.91 | PPARA (0.39) | DPP4PPARAKMT2AMEN1KDM4E | |
| SCHEMBL7288445 | 0.91 | PPARA (0.37) | DPP4PPARAKMT2AMEN1KDM4E | |
| SCHEMBL10774997 | 0.88 | FKBP1A (0.43) | DPP4RENPPARAKMT2AMEN1 | |
| SCHEMBL7268384 | 0.88 | FKBP1A (0.43) | DPP4RENPPARAKMT2AMEN1 | |
| SCHEMBL7268378 | 0.88 | FKBP1A (0.43) | DPP4RENPPARAKMT2AMEN1 | |
| SCHEMBL7292195 | 0.87 | KMT2A (0.39) | PPARAKMT2AMEN1SMN1; SMN2FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0274259-B1 | New renin-inhibitory oligopeptides, their preparaton and their use | SANKYO CO (JP) | 1994-02-16 | — | — | EP | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |