Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CCKBR | P32239 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288366 | 0.92 | PPARA (0.38) | PPARAKMT2ADPP4KDM4EAPOBEC3A | |
| SCHEMBL7291357 | 0.92 | PPARA (0.38) | PPARAKMT2ADPP4KDM4EAPOBEC3A | |
| SCHEMBL7273286 | 0.91 | MAPT (0.41) | PPARAKMT2AHSD17B10KDM4EMEN1 | |
| SCHEMBL7273674 | 0.91 | DPP4 (0.40) | PPARAKMT2ADPP4KDM4EMEN1 | |
| SCHEMBL7273664 | 0.91 | DPP4 (0.40) | PPARAKMT2ADPP4KDM4EMEN1 | |
| SCHEMBL7288445 | 0.90 | PPARA (0.37) | PPARAKMT2ADPP4KDM4EAPOBEC3A | |
| SCHEMBL7292195 | 0.88 | KMT2A (0.39) | PPARAKMT2AMEN1TACR1TP53 | |
| SCHEMBL7296207 | 0.84 | PPARA (0.41) | PPARAKMT2ACHRM1KDM4EMEN1 | |
| SCHEMBL7312186 | 0.83 | PPARA (0.42) | PPARAKMT2ATACR1 | |
| SCHEMBL7273333 | 0.82 | CASP1 (0.40) | PPARAKMT2AKDM4EMEN1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |