Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273674 | 0.92 | DPP4 (0.40) | MAPTKDM4EALDH1A1SMN1; SMN2PPARA | |
| SCHEMBL7273664 | 0.92 | DPP4 (0.40) | MAPTKDM4EALDH1A1SMN1; SMN2PPARA | |
| SCHEMBL7288366 | 0.92 | PPARA (0.38) | KDM4EALDH1A1GAAOPRK1PPARA | |
| SCHEMBL7287672 | 0.91 | PPARA (0.39) | KDM4EALDH1A1HSD17B10PPARAKMT2A | |
| SCHEMBL7291357 | 0.91 | PPARA (0.38) | KDM4EALDH1A1CYP3A4GAAOPRK1 | |
| SCHEMBL7288445 | 0.89 | PPARA (0.37) | KDM4EPPARAKMT2AMEN1 | |
| SCHEMBL7292195 | 0.85 | KMT2A (0.39) | CYP2C19SMN1; SMN2POLBPPARAKMT2A | |
| SCHEMBL7312186 | 0.82 | PPARA (0.42) | PPARAKMT2A | |
| SCHEMBL7273333 | 0.81 | CASP1 (0.40) | MAPTKDM4ECYP3A4PPARANPC1 | |
| SCHEMBL7296207 | 0.81 | PPARA (0.41) | KDM4EALDH1A1CYP3A4CYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0274259-B1 | New renin-inhibitory oligopeptides, their preparaton and their use | SANKYO CO (JP) | 1994-02-16 | — | — | EP | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |