Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 14/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | PDE6D | O43924 | 2/20 | 0.35 |
| ▸ | PDE6A | P16499 | 2/20 | 0.35 |
| ▸ | PDE6G | P18545 | 2/20 | 0.35 |
| ▸ | PDE6B | P35913 | 2/20 | 0.35 |
| ▸ | PDE6C | P51160 | 2/20 | 0.35 |
| ▸ | PDE6H | Q13956 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276444 | 0.82 | MAPT (0.41) | PDE5ACYP2C9 | |
| SCHEMBL7284955 | 0.81 | AR (0.38) | PDE5AARCYP2C9 | |
| SCHEMBL7274146 | 0.80 | CSF1R (0.38) | CSF1RPDE5ACYP2C9 | |
| SCHEMBL7282033 | 0.79 | TUBB4A (0.40) | CSF1RCYP2C9 | |
| SCHEMBL7281994 | 0.73 | ALDH1A1 (0.41) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL10563236 | 0.72 | ALDH1A1 (0.39) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7284246 | 0.70 | CYP19A1 (0.45) | CSF1R | |
| SCHEMBL7274014 | 0.70 | TUBB4A (0.40) | CSF1RCYP2C9 | |
| SCHEMBL7284359 | 0.70 | CYP2C9 (0.41) | CSF1RCYP2C9 | |
| SCHEMBL7273897 | 0.69 | ALDH1A1 (0.52) | CSF1RCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5061798-A | Intermediates in the formation of synthetic hormones, mimic effects of thyroid hormones; little or no effect on the heart | SMITH KLINE & FRENCH LABORATORIES, LTD. (GB) | 1991-10-29 | — | — | US | disclosed |
| EP-0188351-B1 | CHEMICAL COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-03-13 | — | — | EP | disclosed |
| US-4910305-A | Containing a protected 4-hydroxyphenyl | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-03-20 | — | — | US | disclosed |
| US-4826876-A | WITHOUT EFFECT ON HEART | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-05-02 | — | — | US | disclosed |
| US-4766121-A | NOT AFFECTING THE HEART | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1988-08-23 | — | — | US | disclosed |
| EP-0188351-A2 | Chemical compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-07-23 | — | — | EP | disclosed |