Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 3/20 | 0.31 |
| ▸ | PDE6D | O43924 | 1/20 | 0.31 |
| ▸ | PDE6A | P16499 | 1/20 | 0.31 |
| ▸ | PDE6G | P18545 | 1/20 | 0.31 |
| ▸ | PDE6B | P35913 | 1/20 | 0.31 |
| ▸ | PDE6C | P51160 | 1/20 | 0.31 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 3/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281994 | 0.96 | ALDH1A1 (0.41) | ALDH1A1RECQLMAPK1SMN1; SMN2ATM | |
| SCHEMBL10413380 | 0.74 | CYP1A2 (0.33) | ALDH1A1SMN1; SMN2CYP2C9 | |
| SCHEMBL7276444 | 0.72 | MAPT (0.41) | ALDH1A1RECQLSMN1; SMN2PDE5ACYP2C9 | |
| SCHEMBL7273774 | 0.72 | CSF1R (0.40) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL5363739 | 0.68 | ALDH1A1 (0.60) | ALDH1A1RECQLMAPK1SMN1; SMN2ATM | |
| SCHEMBL7285771 | 0.68 | ALDH1A1 (0.33) | ALDH1A1PDE5APDE6DPDE6APDE6G | |
| SCHEMBL7282033 | 0.67 | TUBB4A (0.40) | CYP2C9 | |
| SCHEMBL7285392 | 0.67 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7273900 | 0.67 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL7344141 | 0.67 | ALDH1A1 (0.46) | ALDH1A1RECQLMAPK1ATMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4826876-A | WITHOUT EFFECT ON HEART | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-05-02 | — | — | US | disclosed |