Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MASP2 | O00187 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | FABP6 | P51161 | 2/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CBFB | Q13951 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ILK | Q13418 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL727388 | 0.86 | PLAU (0.61) | TYMSALDH1A1MASP2MEN1NUDT1 | |
| SCHEMBL15938795 | 0.84 | ALDH1A1 (0.50) | TYMSALDH1A1MASP2MEN1NUDT1 | |
| SCHEMBL5681591 | 0.82 | TYMS (0.52) | TYMSALDH1A1MASP2MEN1NUDT1 | |
| SCHEMBL3597284 | 0.80 | MEN1 (0.54) | ALDH1A1MASP2MEN1NUDT1KMT2A | |
| SCHEMBL5679917 | 0.79 | FABP6 (0.47) | TYMSALDH1A1MASP2MEN1NUDT1 | |
| SCHEMBL19364508 | 0.79 | HSD17B10 (0.40) | TYMSHSD17B10CBFBTDP1ILK | |
| SCHEMBL6324712 | 0.79 | HSD17B10 (0.40) | TYMSHSD17B10CBFBTDP1ILK | |
| SCHEMBL889001 | 0.79 | HSD17B10 (0.47) | ALDH1A1MEN1KMT2AHSD17B10CBFB | |
| SCHEMBL23800775 | 0.78 | XDH (0.50) | TYMSALDH1A1MASP2MEN1NUDT1 | |
| SCHEMBL11718240 | 0.78 | AOC3 (0.53) | ALDH1A1MASP2MEN1NUDT1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2953944-B1 | PYRIDAZINONE-AMIDES DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-04-26 | — | — | EP | disclosed |
| US-20170071936-A1 | PYRIDAZINONE-AMIDES DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| US-9567320-B2 | Pyridazinone-amides derivatives | MERCK PATENT GMBH (DE) | 2017-02-14 | — | — | US | disclosed |
| US-20150376167-A1 | PYRIDAZINONE-AMIDES DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-12-31 | — | — | US | disclosed |
| EP-2953944-A1 | PYRIDAZINONE-AMIDES DERIVATIVES | Merck Patent GmbH (DE) | 2015-12-16 | — | — | EP | disclosed |
| CN-102917775-B | There is the PA membrane of the coating comprising polyalkylene oxide and imidazolium compounds | DOW GLOBAL TECHNOLOGIES LLC (US) | 2015-11-25 | — | — | CN | disclosed |
| WO-2014121931-A1 | PYRIDAZINONE-AMIDES DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-08-14 | — | — | WO | disclosed |
| US-8646616-B2 | Composite membrane with coating comprising polyalkylene oxide and imidazol compounds | DOW GLOBAL TECHNOLOGIES LLC (US) | 2014-02-11 | — | — | US | disclosed |
| CN-102917775-A | Polyamide membrane with coating comprising polyalkylene oxide and imidazol compounds | DOW GLOBAL TECHNOLOGIES LLC | 2013-02-06 | — | — | CN | disclosed |
| WO-2011149572-A1 | POLYAMIDE MEMBRANE WITH COATING COMPRISING POLYALKYLENE OXIDE AND IMIDAZOL COMPOUNDS | DOW GLOBAL TECHNOLOGIES LLC (US) | 2011-12-01 | — | — | WO | disclosed |
| US-20110284454-A1 | COMPOSITE MEMBRANE WITH COATING COMPRISING POLYALKYLENE OXIDE AND IMIDAZOL COMPOUNDS | DOW GLOBAL TECHNOLOGIES LLC | 2011-11-24 | — | — | US | disclosed |
| US-4550118-A | ANTIULCER, ANTISECRETORY AGENT, HISTAMINE ANTAGONIST | IKEDA MOHANDO CO., LTD. (JP) | 1985-10-29 | — | — | US | disclosed |
| EP-0111685-A1 | Benzazoles as histamine H2 receptor antagonists | Ikeda Mohando Co., Ltd. (JP) | 1984-06-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170071936-A1 | PYRIDAZINONE-AMIDES DERIVATIVES | CNKSR1, SSB, NQO2 | TYMS 997/4885ALDH1A1 108/4885MASP2 2403/4885 |
| US-20150376167-A1 | PYRIDAZINONE-AMIDES DERIVATIVES | CNKSR1, SSB, NQO2 | TYMS 997/4885ALDH1A1 108/4885MASP2 2403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.