SCHEMBL7273950

SCHEMBL7273950

CC[C@H](C)[C@H](N)C(=O)NCC(C)C

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.45
CYP2C19 P33261 1/20 0.45
TERT O14746 1/20 0.43
DPP4 P27487 4/20 0.41
DPP8 Q6V1X1 4/20 0.41
DPP9 Q86TI2 4/20 0.41
MMP1 P03956 1/20 0.39
MMP8 P22894 1/20 0.39
GPR88 Q9GZN0 4/20 0.38
MME P08473 1/20 0.38
ACE P12821 1/20 0.38
CPA1 P15085 1/20 0.38
ACE2 Q9BYF1 1/20 0.38
EPHX1 P07099 1/20 0.38
DPP7 Q9UHL4 3/20 0.37
HPGD P15428 1/20 0.37
ANPEP P15144 1/20 0.36
DNPEP Q9ULA0 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3160851 0.86 TERT (0.43) TERTDPP4DPP8DPP9GPR88
SCHEMBL3667413 0.83 TERT (0.46) TERTDPP4DPP8DPP9MME
SCHEMBL12259750 0.83 TERT (0.46) TERTDPP4DPP8DPP9MME
SCHEMBL7330431 0.81 CYP2D6 (0.50) CYP2D6CYP2C19DPP4DPP8DPP9
SCHEMBL3374178 0.81 CYP2D6 (0.50) CYP2D6CYP2C19DPP4DPP8DPP9
SCHEMBL25327286 0.80 TERT (0.43) TERTDPP4DPP8DPP9MME
SCHEMBL8533422 0.80 TERT (0.43) TERTDPP4DPP8DPP9MME
SCHEMBL8260358 0.80 TERT (0.43) TERTDPP4DPP8DPP9MME
SCHEMBL19919650 0.80 TERT (0.43) TERTDPP4DPP8DPP9MME
Hydrochloric Acid SCHEMBL7328608 0.79 CYP2D6 (0.48) CYP2D6CYP2C19DPP4DPP8DPP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5446161-A Protease inhibitor, viricides HOFFMANN-LA ROCHE INC. (US) 1995-08-29 US disclosed
EP-0346847-B1 Amino acid derivatives HOFFMANN LA ROCHE (CH) 1994-05-11 EP disclosed
EP-0386611-A2 Amino acid derivatives F. HOFFMANN-LA ROCHE AG (CH) 1990-09-12 EP disclosed
EP-0346847-A2 Amino acid derivatives F. HOFFMANN-LA ROCHE AG (CH) 1989-12-20 EP disclosed