Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | EED | O75530 | 1/20 | 0.42 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.42 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.42 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.42 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18226799 | 0.87 | DPP4 (0.51) | HPGDDPP4RECQLEPHX1GPR119 | |
| SCHEMBL25924200 | 0.87 | HPGD (0.49) | HPGDDPP4RECQLEPHX1GPR119 | |
| SCHEMBL16225010 | 0.84 | DPP4 (0.42) | HPGDDPP4RECQLEPHX1GPR119 | |
| SCHEMBL19286080 | 0.84 | GPR119 (0.54) | HPGDDPP4RECQLEPHX1GPR119 | |
| SCHEMBL16212547 | 0.83 | DPP4 (0.42) | HPGDDPP4RECQLEPHX1GPR119 | |
| SCHEMBL25343622 | 0.83 | HPGD (0.54) | HPGDDPP4RECQLEPHX1GPR119 | |
| SCHEMBL6132431 | 0.82 | HPGD (0.45) | HPGDDPP4RECQLEPHX1GPR119 | |
| SCHEMBL1892198 | 0.81 | HPGD (0.53) | HPGDDPP4RECQLEPHX1GPR119 | |
| SCHEMBL31352385 | 0.81 | HPGD (0.47) | HPGDDPP4RECQLEPHX1GPR119 | |
| SCHEMBL5341723 | 0.80 | HPGD (0.54) | HPGDDPP4RECQLEPHX1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040317-A | AN ANTIAGGLOMERANTS USEFUL IN THE PREVENTION AND TREATMENT OF DISEASES CAUSED BY THROMBUS FORMATION | MERCK & CO., INC. (US) | 2000-03-21 | — | — | US | disclosed |
| EP-0743302-B1 | Sulfonamide fibrinogen receptor antagonists | MERCK & CO INC (US) | 1999-08-04 | — | — | EP | disclosed |
| US-5880136-A | PREVENTING THROMBUS FORMATION | MERCK & CO., INC. (US) | 1999-03-09 | — | — | US | disclosed |
| US-5814643-A | ANTICOAGULANTS | MERCK & CO., INC. (US) | 1998-09-29 | — | — | US | disclosed |
| US-5658929-A | ANTICOAGULANTS | MERCK & CO., INC. (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0478363-B1 | Novel sulfonamide fibrinogen receptor antagonists | MERCK & CO INC (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0743302-A2 | Sulfonamide fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1996-11-20 | — | — | EP | disclosed |
| EP-0528587-B1 | Inhibiting osteoclast-mediated bone resorption using substituted phenyl derivatives | MERCK & CO INC (US) | 1995-02-22 | — | — | EP | disclosed |
| US-5292756-A | Novel sulfonamide fibrinogen receptor antagonists | MERCK & CO., INC. (US) | 1994-03-08 | — | — | US | disclosed |
| WO-1993019046-A1 | NOVEL SULFONAMIDE FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1993-09-30 | — | — | WO | disclosed |
| US-5217994-A | METHOD OF INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION BY ADMINISTRATION OF AMINOALKYL-SUBSTITUTED PHENYL DERIVATIVES | MERCK & CO., INC. (US) | 1993-06-08 | — | — | US | disclosed |
| US-5204350-A | Treating osteoporosis | MERCK & CO., INC. (US) | 1993-04-20 | — | — | US | disclosed |
| EP-0528587-A1 | Inhibiting osteoclast-mediated bone resorption using substituted phenyl derivatives | MERCK & CO. INC. (US) | 1993-02-24 | — | — | EP | disclosed |
| EP-0528586-A1 | Inhibiting osteoclast-mediated bone resorption using aminoalkyl-substituted phenyl derivatives | MERCK & CO. INC. (US) | 1993-02-24 | — | — | EP | disclosed |
| EP-0478363-A2 | Novel sulfonamide fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1992-04-01 | — | — | EP | disclosed |