Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.61 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.57 |
| ▸ | CTSL | P07711 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 3/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.56 |
| ▸ | MMP3 | P08254 | 1/20 | 0.56 |
| ▸ | FCER2 | P06734 | 2/20 | 0.55 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7266645 | 0.91 | CAPN1 (0.62) | CAPN1CTSLHTRA1CTSK | |
| SCHEMBL9417332 | 0.88 | REN (0.58) | RENCAPN1PTPN1CTSLMMP1 | |
| SCHEMBL9417293 | 0.87 | REN (0.57) | RENCAPN1PTPN1CTSLMMP1 | |
| SCHEMBL9417292 | 0.87 | REN (0.57) | RENCAPN1PTPN1CTSLMMP1 | |
| SCHEMBL21786578 | 0.87 | PTPN1 (0.66) | RENCAPN1PTPN1CTSLHTRA1 | |
| SCHEMBL10801015 | 0.86 | CTSL (0.54) | RENCTSLMMP1FCER2CTSK | |
| SCHEMBL31705215 | 0.86 | CAPN1 (0.74) | RENCAPN1PTPN1CTSLHTRA1 | |
| SCHEMBL7302253 | 0.85 | FCER2 (0.61) | RENPTPN1MMP1MMP2MMP3 | |
| SCHEMBL8897141 | 0.85 | REN (0.81) | RENCTSLMMP1MMP2MMP3 | |
| SCHEMBL30140924 | 0.85 | REN (0.81) | RENCTSLMMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229667-B1 | Peptidylaminodiols | ABBOTT LAB (US) | 1994-07-13 | — | — | EP | disclosed |
| US-5258362-A | Enzyme inhibitors, amides with oxetane ring | ABBOTT LABORATORIES (US) | 1993-11-02 | — | — | US | disclosed |
| US-5214129-A | Amidation of a protected amino acid by an di-O-protected dihydroxy-containing amine and coupling with a carboxylic acid; deprotecting; renin inhibitors; hypotensive agents | ABBOTT LABORATORIES (US) | 1993-05-25 | — | — | US | disclosed |
| WO-1992022313-A1 | RENIN INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1992-12-23 | — | — | WO | disclosed |
| US-5091575-A | Renin inhibitor | ABBOTT LABORATORIES (US) | 1992-02-25 | — | — | US | disclosed |
| US-5032577-A | Hypotensive | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| US-4977277-A | INTERMEDIATES FOR RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-12-11 | — | — | US | disclosed |
| EP-0295294-A4 | PEPTIDYLAMINODIOLS. | ABBOTT LAB (US) | 1990-04-10 | — | — | EP | disclosed |
| US-4845079-A | HYPOTENSIVE, RENIN INHIBITION | ABBOTT LABORATORIES | 1989-07-04 | — | — | US | disclosed |
| US-4837204-A | RENIN INHIBITORS; HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0295294-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-12-21 | — | — | EP | disclosed |
| WO-1988005050-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-07-14 | — | — | WO | disclosed |
| EP-0230266-A2 | Functionalized peptidyl aminodiols and -triols | ABBOTT LABORATORIES (US) | 1987-07-29 | — | — | EP | disclosed |
| EP-0229667-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1987-07-22 | — | — | EP | disclosed |
| EP-0189203-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1986-07-30 | — | — | EP | disclosed |