Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273914 | 0.84 | ADRA2C (0.35) | KDM4ECYP11B1CYP11B2SIRT2 | |
| SCHEMBL846 | 0.81 | CYP11B1 (0.34) | MEN1KMT2ACYP3A4MAPTCYP11B1 | |
| SCHEMBL9585649 | 0.81 | TAAR1 (0.35) | CYP11B1CYP11B2 | |
| SCHEMBL7310245 | 0.81 | CYP11B1 (0.34) | MEN1KMT2AKDM4ECYP11B1CYP11B2 | |
| SCHEMBL9756933 | 0.79 | MEN1 (0.37) | MEN1KMT2AKDM4ECYP3A4MAPT | |
| SCHEMBL6743058 | 0.79 | CYP11B1 (0.33) | MEN1KMT2ACYP11B1CYP11B2 | |
| SCHEMBL10457156 | 0.78 | P2RX3 (0.36) | MEN1KMT2AKDM4EMAPTCYP11B1 | |
| SCHEMBL8183968 | 0.77 | SMO (0.37) | CYP11B1CYP11B2 | |
| SCHEMBL6667217 | 0.77 | CYP11B1 (0.37) | KDM4EMAPTCYP11B1CYP11B2 | |
| SCHEMBL6662261 | 0.75 | KDM4E (0.34) | KDM4ECYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114950-A | Psychological disorders, anxiety, nausea and vomiting | GLAXO GROUP LIMITED (GB) | 1992-05-19 | — | — | US | disclosed |
| US-5102901-A | 5-hydroxytrypamine receptor antaonists | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1992-04-07 | — | — | US | disclosed |
| US-5037844-A | 5-hydroxytryptamine antagonist | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1991-08-06 | — | — | US | disclosed |
| US-5026722-A | Antagonists of 5-hydroxytryptamine | GLAXO GROUP LIMITED (GB) | 1991-06-25 | — | — | US | disclosed |
| EP-0410509-A1 | New substituted 1H-indazole-3-carboxamides | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1991-01-30 | — | — | EP | disclosed |
| US-4985424-A | Certain substituted 1,7-annelated 1h-indazoles being selective antagonists of 5-ht-receptors | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1991-01-15 | — | — | US | disclosed |
| EP-0393766-A2 | New 3-N substituted carbamoyl-indole derivatives | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1990-10-24 | — | — | EP | disclosed |
| US-4950759-A | ANTAGONISTS OF NEURONAL 5-HYDROXYTRYPTAMINE(5-HT) RECEPTORS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1990-08-21 | — | — | US | disclosed |
| EP-0350130-A2 | New substituted 1,7-annelated 1H-indazoles | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1990-01-10 | — | — | EP | disclosed |
| EP-0347229-A1 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-12-20 | — | — | EP | disclosed |