Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1003836 | 0.81 | CYP11B1 (0.34) | MEN1KMT2ACYP3A4MAPTCYP11B1 | |
| SCHEMBL7404048 | 0.81 | ALDH1A1 (0.36) | MEN1KMT2ACYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL1006291 | 0.81 | TAAR1 (0.35) | CYP11B1CYP11B2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL7274096 | 0.79 | MEN1 (0.37) | MEN1KMT2AKDM4ECYP3A4MAPT | |
| SCHEMBL7415167 | 0.79 | ALDH1A1 (0.34) | MEN1KMT2ACYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL7434512 | 0.78 | ATP4A (0.32) | MEN1KMT2AKDM4ECYP3A4CYP11B1 | |
| SCHEMBL7534704 | 0.78 | HIF1A (0.37) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10439558 | 0.75 | CYP1A2 (0.44) | MEN1KMT2AKDM4ECYP3A4MAPT | |
| SCHEMBL5063081 | 0.74 | LTA4H (0.43) | ALDH1A1 | |
| SCHEMBL7437163 | 0.73 | ALDH1A1 (0.31) | ALDH1A1CYP1A2CYP2D6HPGDHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037844-A | 5-hydroxytryptamine antagonist | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1991-08-06 | — | — | US | disclosed |
| US-4985424-A | Certain substituted 1,7-annelated 1h-indazoles being selective antagonists of 5-ht-receptors | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1991-01-15 | — | — | US | disclosed |
| US-4950759-A | ANTAGONISTS OF NEURONAL 5-HYDROXYTRYPTAMINE(5-HT) RECEPTORS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1990-08-21 | — | — | US | disclosed |