Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1A | P07327 | 4/20 | 0.38 |
| ▸ | ADH1C | P00326 | 3/20 | 0.38 |
| ▸ | ADH1B | P00325 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3285529 | 1.00 | ADH1A (0.38) | ADH1AADH1CADH1BGAATSHR | |
| SCHEMBL3285531 | 0.98 | ADH1C (0.35) | ADH1AADH1CADH1BGAATSHR | |
| SCHEMBL3671338 | 0.97 | ADH1B (0.33) | ADH1AADH1CADH1BBTK | |
| SCHEMBL3671340 | 0.97 | ADH1B (0.33) | ADH1AADH1CADH1BBTK | |
| SCHEMBL14666763 | 0.84 | ADH1B (0.38) | ADH1AADH1CADH1BGAATSHR | |
| SCHEMBL647264 | 0.81 | TSHR (0.37) | ADH1AADH1CADH1BGAATSHR | |
| SCHEMBL9744375 | 0.81 | TSHR (0.37) | ADH1AADH1CADH1BGAATSHR | |
| SCHEMBL9744380 | 0.81 | TSHR (0.37) | ADH1AADH1CADH1BGAATSHR | |
| SCHEMBL2712968 | 0.81 | TSHR (0.37) | ADH1AADH1CADH1BGAATSHR | |
| SCHEMBL4328796 | 0.81 | TSHR (0.37) | ADH1AADH1CADH1BGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703129-A | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-12-30 | — | — | US | disclosed |
| EP-0778266-A1 | 5-Amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of beta-amyloid protein production | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0401676-B1 | Enzyme inhibitors | BIO MEGA BOEHRINGER INGELHEIM (CA) | 1995-01-11 | — | — | EP | disclosed |
| US-5346887-A | Mixture of tripeptide renin inhibitor and steroid antiinflammatory agent | ABBOTT LABORATORIES (US) | 1994-09-13 | — | — | US | disclosed |
| EP-0229667-B1 | Peptidylaminodiols | ABBOTT LAB (US) | 1994-07-13 | — | — | EP | disclosed |
| EP-0255082-B1 | Renin-inhibiting di- and tripeptides, methods for their production, drugs containing them, and their use | HOECHST AG (DE) | 1993-12-01 | — | — | EP | disclosed |
| US-5214129-A | Amidation of a protected amino acid by an di-O-protected dihydroxy-containing amine and coupling with a carboxylic acid; deprotecting; renin inhibitors; hypotensive agents | ABBOTT LABORATORIES (US) | 1993-05-25 | — | — | US | disclosed |
| US-5212157-A | Tetrapeptides as inhibitors of HIV | BIO-MEGA, INC. (CA) | 1993-05-18 | — | — | US | disclosed |
| US-5091575-A | Renin inhibitor | ABBOTT LABORATORIES (US) | 1992-02-25 | — | — | US | disclosed |
| US-5059589-A | Glaucoma treatment | ABBOTT LABORATORIES (US) | 1991-10-22 | — | — | US | disclosed |
| WO-1988005050-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-07-14 | — | — | WO | disclosed |
| EP-0258289-A1 | PEPTIDE ANALOGS | ABBOTT LABORATORIES (US) | 1988-03-09 | — | — | EP | disclosed |
| US-4725583-A | ANTIHYPERTENSIVE | ABBOTT LABORATORIES (US) | 1988-02-16 | — | — | US | disclosed |
| EP-0255082-A2 | Renin-inhibiting di- and tripeptides, methods for their production, drugs containing them, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-02-03 | — | — | EP | disclosed |
| WO-1987004349-A1 | PEPTIDE ANALOGS | DELLARIA JOSEPH | 1987-07-30 | — | — | WO | disclosed |
| EP-0230242-A2 | Substituted derivatives of 4-amino-3-hydroxy-butyric acid, process for their production, medicines containing them, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-07-29 | — | — | EP | disclosed |
| EP-0230266-A2 | Functionalized peptidyl aminodiols and -triols | ABBOTT LABORATORIES (US) | 1987-07-29 | — | — | EP | disclosed |
| EP-0229667-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1987-07-22 | — | — | EP | disclosed |
| EP-0189203-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1986-07-30 | — | — | EP | disclosed |
| EP-0184855-A2 | Resin inhibiting compounds | ABBOTT LABORATORIES (US) | 1986-06-18 | — | — | EP | disclosed |