Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274466 | 0.95 | ALDH1A1 (0.59) | HPGDSLC2A1MEN1KMT2ACYP1A2 | |
| SCHEMBL7273703 | 0.94 | HPGD (0.56) | HPGDSLC2A1MEN1KMT2ACYP1A2 | |
| SCHEMBL7286125 | 0.93 | SLC2A1 (0.60) | HPGDSLC2A1MEN1KMT2ACYP1A2 | |
| SCHEMBL7272560 | 0.93 | MEN1 (0.55) | HPGDMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL7273951 | 0.92 | HPGD (0.57) | HPGDMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL7279369 | 0.92 | HPGD (0.57) | HPGDSLC2A1MEN1KMT2ACYP1A2 | |
| SCHEMBL7295690 | 0.92 | SLC2A1 (0.57) | HPGDSLC2A1MEN1KMT2ACYP1A2 | |
| SCHEMBL7294870 | 0.92 | SLC2A1 (0.70) | HPGDSLC2A1MEN1KMT2ACYP1A2 | |
| SCHEMBL7445759 | 0.91 | SLC2A1 (0.72) | SLC2A1MEN1KMT2AHDAC1HDAC6 | |
| SCHEMBL7433595 | 0.91 | SLC2A1 (0.72) | SLC2A1MEN1KMT2AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4885313-A | 3,4-Dihydroxyphenylethylamine derivatives and their use | FISONS PLC (GB) | 1989-12-05 | — | — | US | disclosed |
| US-4803225-A | Dihydroxy-phenethylamino compounds useful as pharmaceuticals | FISONS, PLC (GB) | 1989-02-07 | — | — | US | disclosed |
| US-4720586-A | Substituted 3,4-dihydroxy-phenylethylamino compounds | FISONS, PLC (GB) | 1988-01-19 | — | — | US | disclosed |
| EP-0142283-A2 | Phenylethylamines, process for their preparation and compositions containing them | FISONS plc (GB) | 1985-05-22 | — | — | EP | disclosed |