SCHEMBL7274399

SCHEMBL7274399

NCCCCCC(=O)NC[C@@H]1C[C@@H](CC(=O)O)C(=O)N1CCc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 1/20 0.42
MTNR1A P48039 1/20 0.42
F13A1 P00488 1/20 0.40
ALDH1A1 P00352 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
HDAC3 O15379 4/20 0.38
HDAC1 Q13547 4/20 0.38
HDAC2 Q92769 4/20 0.38
HDAC10 Q969S8 4/20 0.38
HDAC11 Q96DB2 4/20 0.38
HDAC8 Q9BY41 4/20 0.38
HDAC6 Q9UBN7 4/20 0.38
HDAC4 P56524 3/20 0.38
HDAC7 Q8WUI4 3/20 0.38
HDAC9 Q9UKV0 3/20 0.38
HDAC5 Q9UQL6 3/20 0.38
NCOR2 Q9Y618 1/20 0.38
CYP3A4 P08684 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7272956 0.95 MMP2 (0.41) MMP2MTNR1AF13A1ALDH1A1SMN1; SMN2
SCHEMBL7281757 0.95 MMP2 (0.41) MMP2MTNR1AF13A1ALDH1A1SMN1; SMN2
SCHEMBL7281946 0.95 MMP2 (0.41) MMP2MTNR1AF13A1ALDH1A1SMN1; SMN2
SCHEMBL7283915 0.94 SIGMAR1 (0.41) MMP2MTNR1AF13A1ALDH1A1SMN1; SMN2
SCHEMBL7282210 0.91 SIGMAR1 (0.44) MTNR1AF13A1ALDH1A1SMN1; SMN2CYP3A4
SCHEMBL7272799 0.90 HDAC1 (0.41) MMP2F13A1HDAC3HDAC1HDAC2
SCHEMBL7283508 0.90 HDAC3 (0.44) MMP2MTNR1AF13A1ALDH1A1SMN1; SMN2
SCHEMBL7274864 0.88 NAMPT (0.40) MTNR1AF13A1ALDH1A1SMN1; SMN2HDAC3
SCHEMBL7274292 0.87 MMP2 (0.41) MMP2MTNR1AALDH1A1SMN1; SMN2HDAC3
SCHEMBL7283712 0.87 CA12 (0.38) MTNR1AHDAC3HDAC1HDAC2HDAC10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5591769-A PYRROLIDINE DERIVATIVES; ANTICOAGULANTS KARL THOMAE GMBH (DE) 1997-01-07 US disclosed
US-5541343-A ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS KARL THOMAE GMBH (DE) 1996-07-30 US disclosed
EP-0483667-A2 Cyclic imino derivatives, process for their preparation and drugs containing them Dr. Karl Thomae GmbH (DE) 1992-05-06 EP disclosed