SCHEMBL7274292

SCHEMBL7274292

NCCCCCC(=O)NC[C@@H]1C[C@@H](CCC(=O)O)C(=O)N1CCCc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 1/20 0.41
SIGMAR1 Q99720 2/20 0.40
ALDH1A1 P00352 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
LMNA P02545 1/20 0.39
TSHR P16473 1/20 0.39
MTNR1A P48039 1/20 0.39
NAMPT P43490 2/20 0.38
MAPT P10636 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
HDAC1 Q13547 2/20 0.37
HDAC2 Q92769 2/20 0.37
HDAC3 O15379 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
HDAC9 Q9UKV0 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7274361 0.99 SIGMAR1 (0.41) MMP2SIGMAR1ALDH1A1SMN1; SMN2LMNA
SCHEMBL7281757 0.92 MMP2 (0.41) MMP2SIGMAR1ALDH1A1SMN1; SMN2LMNA
SCHEMBL7281946 0.92 MMP2 (0.41) MMP2SIGMAR1ALDH1A1SMN1; SMN2LMNA
SCHEMBL7272956 0.92 MMP2 (0.41) MMP2SIGMAR1ALDH1A1SMN1; SMN2LMNA
SCHEMBL7283915 0.91 SIGMAR1 (0.41) MMP2SIGMAR1ALDH1A1SMN1; SMN2LMNA
Water SCHEMBL7275711 0.88 LMNA (0.42) ALDH1A1SMN1; SMN2LMNATSHRNAMPT
SCHEMBL7282210 0.88 SIGMAR1 (0.44) SIGMAR1ALDH1A1SMN1; SMN2LMNATSHR
SCHEMBL7280925 0.88 LMNA (0.43) ALDH1A1SMN1; SMN2LMNATSHRNAMPT
SCHEMBL8943732 0.87 LTA4H (0.42) SIGMAR1ALDH1A1LMNATSHRMTNR1A
SCHEMBL7274399 0.87 MMP2 (0.42) MMP2SIGMAR1ALDH1A1SMN1; SMN2MTNR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5591769-A PYRROLIDINE DERIVATIVES; ANTICOAGULANTS KARL THOMAE GMBH (DE) 1997-01-07 US disclosed
US-5541343-A ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS KARL THOMAE GMBH (DE) 1996-07-30 US disclosed
EP-0483667-A2 Cyclic imino derivatives, process for their preparation and drugs containing them Dr. Karl Thomae GmbH (DE) 1992-05-06 EP disclosed