Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2163526 | 0.84 | L3MBTL1 (0.57) | MAPTALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL7282605 | 0.81 | CYP11B1 (0.50) | MAPTALDH1A1SMN1; SMN2CYP2D6HRH3 | |
| Hydrochloric Acid SCHEMBL7275507 | 0.81 | MAPT (0.45) | MAPTALDH1A1SMN1; SMN2GAAFAAH | |
| SCHEMBL7275746 | 0.81 | MAPT (0.44) | MAPTALDH1A1SMN1; SMN2FAAH | |
| Hydrochloric Acid SCHEMBL8571479 | 0.81 | CYP11B1 (0.49) | MAPTALDH1A1SMN1; SMN2CYP2D6HRH3 | |
| SCHEMBL7282021 | 0.80 | CTSG (0.40) | MAPTALDH1A1KMT2A | |
| SCHEMBL7275164 | 0.80 | PPARG (0.40) | ALDH1A1CYP2D6HRH1HRH3 | |
| Hydrochloric Acid SCHEMBL7274073 | 0.80 | ITGB3 (0.55) | MAPTPOLB | |
| SCHEMBL7272668 | 0.80 | CYP11B1 (0.46) | ALDH1A1HRH1 | |
| SCHEMBL25247571 | 0.79 | MAPT (0.47) | MAPTALDH1A1SMN1; SMN2GAAFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |
| US-5650424-A | ANTIAGGLOMERANTS USING IMIDAZOLIDINDIONES | DR. KARL THOMAE GMBH (DE) | 1997-07-22 | — | — | US | disclosed |
| EP-0503548-B1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-06-04 | — | — | EP | disclosed |
| US-5478942-A | Antiinflammatory agents, antiagglomerants | KARL THOMAE GMBH (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5276049-A | Treatment of thrombosis | DR. KARL THOMAE GMBH (DE) | 1994-01-04 | — | — | US | disclosed |
| EP-0503548-A1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |