Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.53 |
| ▸ | CTSD | P07339 | 1/20 | 0.53 |
| ▸ | CTSE | P14091 | 1/20 | 0.53 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9725825 | 1.00 | REN (0.53) | RENCTSDCTSECTSSCTSK | |
| SCHEMBL9725812 | 1.00 | REN (0.53) | RENCTSDCTSECTSSCTSK | |
| SCHEMBL9739264 | 1.00 | REN (0.53) | RENCTSDCTSECTSSCTSK | |
| SCHEMBL9749328 | 0.89 | REN (0.53) | RENCTSDCTSE | |
| SCHEMBL9741114 | 0.85 | REN (0.49) | RENCTSDCTSE | |
| SCHEMBL9513094 | 0.84 | REN (0.62) | RENCTSDCTSE | |
| SCHEMBL9512616 | 0.83 | REN (0.61) | RENCTSDCTSE | |
| SCHEMBL7274657 | 0.81 | REN (0.60) | RENCTSDCTSE | |
| SCHEMBL9725793 | 0.80 | CA1 (0.44) | RENCTSDCTSE | |
| SCHEMBL7289460 | 0.80 | CA1 (0.44) | RENCTSDCTSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5106835-A | Hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-04-21 | — | — | US | disclosed |
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0427939-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |