Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274679 | 0.83 | REN (0.55) | REN | |
| SCHEMBL18229265 | 0.74 | REN (0.68) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22962098 | 0.74 | REN (0.68) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6857159 | 0.74 | REN (0.68) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1913543 | 0.74 | REN (0.68) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23106755 | 0.74 | REN (0.68) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7329655 | 0.72 | REN (0.67) | REN | |
| SCHEMBL8073093 | 0.72 | REN (0.68) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28376535 | 0.72 | REN (0.68) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL18171935 | 0.72 | REN (0.68) | RENPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210545-A2 | Phosphorous containing enzyme inhibitors | MERCK & CO. INC. (US) | 1987-02-04 | — | — | EP | disclosed |
| EP-0209897-A2 | Peptide enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | disclosed |