Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 12/20 | 0.38 |
| ▸ | MGLL | Q99685 | 4/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275714 | 0.97 | FAAH (0.39) | CHRNB4CHRNA3FAAHMGLLELANE | |
| SCHEMBL7281928 | 0.94 | F2 (0.36) | CHRNB4CHRNA3FAAHOPRM1ELANE | |
| SCHEMBL7281067 | 0.92 | MGLL (0.41) | MGLLSIGMAR1KCNH2 | |
| SCHEMBL7274275 | 0.87 | CHRNB4 (0.36) | CHRNB4CHRNA3FAAHSIGMAR1KCNH2 | |
| SCHEMBL7273490 | 0.87 | F2 (0.37) | ELANEF2CTSG | |
| SCHEMBL7275003 | 0.86 | ELANE (0.37) | FAAHMGLLELANEF2CTSG | |
| SCHEMBL7275083 | 0.86 | ALOX12 (0.34) | — | |
| SCHEMBL7275231 | 0.82 | CHRNB4 (0.37) | CHRNB4CHRNA3FAAHMGLLELANE | |
| SCHEMBL7275948 | 0.82 | CHRNB4 (0.37) | CHRNB4CHRNA3FAAHMGLLELANE | |
| SCHEMBL7274379 | 0.82 | FAAH (0.39) | CHRNB4CHRNA3FAAHMGLLOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528369-B1 | Cyclic imino derivatives, pharmaceutical compositions containing them and process for their preparation | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-11-24 | — | — | EP | disclosed |
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| US-5455348-A | Anticoagulants | Thomae, Karl (DE) | 1995-10-03 | — | — | US | disclosed |
| EP-0528369-A2 | Cyclic imino derivatives, pharmaceutical compositions containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-02-24 | — | — | EP | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |