Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 15/20 | 0.44 |
| ▸ | CTRC | Q99895 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7283124 | 0.88 | ELANE (0.49) | POLBTSHRRECQLHSD17B10ELANE | |
| SCHEMBL7283751 | 0.85 | ELANE (0.57) | ELANECTRCNPC1RAB9A | |
| SCHEMBL7277028 | 0.83 | ELANE (0.46) | POLBTSHRRECQLHSD17B10ELANE | |
| SCHEMBL7445689 | 0.81 | ELANE (0.60) | ELANECTRCNPC1RAB9A | |
| SCHEMBL7446091 | 0.81 | ELANE (0.53) | ELANECTRCNPC1RAB9A | |
| SCHEMBL7284545 | 0.80 | HDAC3 (0.52) | ELANECTRCNPC1RAB9AALDH1A1 | |
| SCHEMBL7276667 | 0.78 | ELANE (0.62) | POLBELANECTRC | |
| SCHEMBL7286359 | 0.75 | ELANE (0.60) | ELANECTRC | |
| SCHEMBL6556109 | 0.73 | ELANE (0.51) | ELANENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7283841 | 0.73 | ELANE (0.49) | ELANECTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |