Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 17/20 | 0.49 |
| ▸ | CTRC | Q99895 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274908 | 0.88 | POLB (0.44) | ELANECTRCPOLBTSHRRECQL | |
| SCHEMBL7277028 | 0.85 | ELANE (0.46) | ELANECTRCPOLBTSHRRECQL | |
| SCHEMBL7276488 | 0.85 | ELANE (0.64) | ELANECTRCCASP1NPC1RAB9A | |
| SCHEMBL7286359 | 0.81 | ELANE (0.60) | ELANECTRC | |
| SCHEMBL8536815 | 0.80 | ELANE (0.67) | ELANECTRCCASP1NPC1RAB9A | |
| SCHEMBL8536676 | 0.80 | ELANE (0.59) | ELANECTRCHSD17B10 | |
| SCHEMBL7276853 | 0.79 | HDAC3 (0.53) | ELANECTRCCASP1 | |
| SCHEMBL21685578 | 0.79 | NPC1 (0.50) | ELANECTRCPOLBCASP1NPC1 | |
| SCHEMBL2798490 | 0.79 | ELANE (0.64) | ELANECTRCCASP1NPC1RAB9A | |
| SCHEMBL2802859 | 0.78 | ELANE (0.64) | ELANECTRCCASP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |