Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 16/20 | 0.46 |
| ▸ | CTRC | Q99895 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6282557 | 0.86 | ELANE (0.59) | ELANECTRCNPC1RAB9ACASP1 | |
| SCHEMBL7283124 | 0.85 | ELANE (0.49) | ELANECTRCPOLBNPC1RAB9A | |
| SCHEMBL7274908 | 0.83 | POLB (0.44) | ELANECTRCPOLBKDM4EALDH1A1 | |
| SCHEMBL7440440 | 0.82 | ELANE (0.55) | ELANECTRC | |
| SCHEMBL7274678 | 0.81 | HDAC3 (0.49) | ELANECTRCNPC1RAB9ACASP1 | |
| SCHEMBL7289416 | 0.80 | ELANE (0.64) | ELANECTRC | |
| SCHEMBL7286359 | 0.77 | ELANE (0.60) | ELANECTRC | |
| SCHEMBL7283841 | 0.74 | ELANE (0.49) | ELANECTRC | |
| SCHEMBL6086170 | 0.74 | ELANE (0.62) | ELANECTRCNPC1RAB9A | |
| SCHEMBL7283834 | 0.72 | ELANE (0.54) | ELANECTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |