Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 18/20 | 0.53 |
| ▸ | CTRC | Q99895 | 3/20 | 0.53 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7283751 | 0.93 | ELANE (0.57) | ELANECTRCMGLLNPC1RAB9A | |
| SCHEMBL8536676 | 0.88 | ELANE (0.59) | ELANECTRCMGLL | |
| SCHEMBL7440440 | 0.83 | ELANE (0.55) | ELANECTRCMGLL | |
| SCHEMBL7276667 | 0.83 | ELANE (0.62) | ELANECTRC | |
| SCHEMBL6558159 | 0.83 | ELANE (0.63) | ELANEMGLL | |
| SCHEMBL7445689 | 0.82 | ELANE (0.60) | ELANECTRCNPC1RAB9A | |
| SCHEMBL7284545 | 0.81 | HDAC3 (0.52) | ELANECTRCNPC1RAB9A | |
| SCHEMBL7274908 | 0.81 | POLB (0.44) | ELANECTRCNPC1RAB9A | |
| SCHEMBL7276488 | 0.79 | ELANE (0.64) | ELANECTRCNPC1RAB9A | |
| SCHEMBL7300356 | 0.76 | ELANE (0.61) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636142-B1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LTD (GB) | 1998-06-17 | — | — | EP | disclosed |
| US-5721222-A | Heterocyclic ketones | ZENECA LIMITED (GB) | 1998-02-24 | — | — | US | disclosed |
| US-5486529-A | Certain pyridyl ketones for treating diseases involving leukocyte elastase | ZENECA LIMITED (GB) | 1996-01-23 | — | — | US | disclosed |
| EP-0636142-A1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LIMITED (GB) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021209-A1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |