Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | SMPD2 | O60906 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275466 | 1.00 | KDM4E (0.50) | KDM4EALDH1A1HPGDMEN1GAA | |
| SCHEMBL7273032 | 0.87 | KDM4E (0.44) | KDM4EALDH1A1HPGDMEN1GAA | |
| SCHEMBL7328223 | 0.86 | KDM4E (0.51) | KDM4EALDH1A1HPGDMEN1GAA | |
| SCHEMBL7328215 | 0.86 | KDM4E (0.51) | KDM4EALDH1A1HPGDMEN1GAA | |
| SCHEMBL5698294 | 0.84 | KDM4E (0.52) | KDM4EALDH1A1HPGDMEN1GAA | |
| SCHEMBL3817101 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1HPGDMEN1GAA | |
| SCHEMBL8865007 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1HPGDMEN1GAA | |
| SCHEMBL563351 | 0.83 | KDM4E (0.51) | KDM4EALDH1A1HPGDMEN1GAA | |
| SCHEMBL7971777 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1HPGDMEN1GAA | |
| SCHEMBL8865001 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1HPGDMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0274259-B1 | New renin-inhibitory oligopeptides, their preparaton and their use | SANKYO CO (JP) | 1994-02-16 | — | — | EP | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |