Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.42 |
| ▸ | SMPD2 | O60906 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328215 | 1.00 | KDM4E (0.51) | KDM4ECYP2C19TSHRALDH1A1HPGD | |
| SCHEMBL7275461 | 0.86 | KDM4E (0.50) | KDM4ECYP2C19ALDH1A1HPGDMEN1 | |
| SCHEMBL7275466 | 0.86 | KDM4E (0.50) | KDM4ECYP2C19ALDH1A1HPGDMEN1 | |
| SCHEMBL5698294 | 0.85 | KDM4E (0.52) | KDM4ECYP2C19ALDH1A1HPGDMEN1 | |
| SCHEMBL3964497 | 0.85 | KDM4E (0.47) | KDM4ECYP2C19ALDH1A1HPGDMEN1 | |
| SCHEMBL10477791 | 0.85 | KDM4E (0.50) | KDM4ECYP2C19ALDH1A1HPGDMEN1 | |
| SCHEMBL3964492 | 0.85 | KDM4E (0.47) | KDM4ECYP2C19ALDH1A1HPGDMEN1 | |
| SCHEMBL10477792 | 0.85 | KDM4E (0.50) | KDM4ECYP2C19ALDH1A1HPGDMEN1 | |
| SCHEMBL563351 | 0.84 | KDM4E (0.51) | KDM4ECYP2C19ALDH1A1HPGDMEN1 | |
| SCHEMBL8865007 | 0.84 | KDM4E (0.55) | KDM4ECYP2C19ALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2157243-A | — | — | None | — | — | JP | disclosed |
| EP-0470702-B1 | An optically active morpholino oxobutyric acid hydroxy binaphthalene derivative and its preparation | TAKASAGO PERFUMERY CO LTD (JP) | 1995-09-27 | — | — | EP | disclosed |
| US-5106970-A | OPTICALLY ACTIVE 4-MORPHOLINO-2-(1-NAPHTHYLMETHYL)-4-OXOBUTYRIC ACID 2'-HYDROXY-1,1'BINAPHTHALEN-2-YL | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1992-04-21 | — | — | US | disclosed |
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0470702-A1 | An optically active morpholino oxobutyric acid hydroxy binaphthalene derivative and its preparation | Takasago International Corporation (JP) | 1992-02-12 | — | — | EP | disclosed |
| EP-0427939-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |
| EP-0396065-A1 | Novel amino acid derivatives possessing renin-inhibitory activities | Japan Tobacco Inc. (JP) | 1990-11-07 | — | — | EP | disclosed |
| JP-H02157243-A | PRODUCTION OF OPTICALLY ACTIVE (R)-2-(1-NAPHTHYLMETHYL)-SUCCINIC ACID | KISSEI PHARMACEUT CO LTD | 1990-06-18 | — | — | JP | disclosed |
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| US-4857650-A | Novel renin inhibitory amino acid derivatives | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| US-4853463-A | Amino acid derivatives | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-08-01 | — | — | US | disclosed |
| US-4841067-A | RENIN INHIBITORS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-06-20 | — | — | US | disclosed |
| US-4711958-A | HYPOTENSIVE AGENTS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1987-12-08 | — | — | US | disclosed |
| EP-0244083-A2 | Amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1987-11-04 | — | — | EP | disclosed |
| US-4656269-A | RENIN INHIBITORY EFFECT WHEN ADMINISTERING ORALLY; HYPOTENSIVE AGENTS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1987-04-07 | — | — | US | disclosed |
| EP-0216539-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1987-04-01 | — | — | EP | disclosed |
| EP-0206807-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-12-30 | — | — | EP | disclosed |
| EP-0200406-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-11-05 | — | — | EP | disclosed |
| EP-0190891-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-08-13 | — | — | EP | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |