Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 12/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 11/20 | 0.47 |
| ▸ | EGLN2 | Q96KS0 | 6/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7283006 | 0.84 | CYP11B2 (0.41) | CYP11B2EGLN2SCN9A | |
| SCHEMBL7282701 | 0.80 | KDM4E (0.45) | — | |
| SCHEMBL24990144 | 0.77 | PIM1 (0.50) | CYP11B2CYP11B1EGLN2 | |
| SCHEMBL2713004 | 0.75 | KDM4E (0.49) | CYP11B2SCN9A | |
| SCHEMBL9612021 | 0.74 | CYP11B2 (0.68) | CYP11B2CYP11B1 | |
| SCHEMBL305860 | 0.73 | ALDH1A1 (0.55) | SCN9A | |
| SCHEMBL12496622 | 0.73 | CYP11B2 (0.77) | CYP11B2CYP11B1 | |
| SCHEMBL18297999 | 0.72 | CYP11B2 (0.67) | CYP11B2CYP11B1 | |
| SCHEMBL7275896 | 0.72 | HTR1A (0.47) | — | |
| SCHEMBL7284086 | 0.71 | S1PR1 (0.48) | CYP11B2CYP11B1EGLN2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |
| US-5650424-A | ANTIAGGLOMERANTS USING IMIDAZOLIDINDIONES | DR. KARL THOMAE GMBH (DE) | 1997-07-22 | — | — | US | disclosed |
| EP-0503548-B1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-06-04 | — | — | EP | disclosed |
| US-5478942-A | Antiinflammatory agents, antiagglomerants | KARL THOMAE GMBH (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5276049-A | Treatment of thrombosis | DR. KARL THOMAE GMBH (DE) | 1994-01-04 | — | — | US | disclosed |
| EP-0503548-A1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |