Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281972 | 0.92 | SIGMAR1 (0.43) | SIGMAR1LTA4HNAMPTALDH1A1DRD2 | |
| SCHEMBL7282148 | 0.89 | SIGMAR1 (0.43) | SIGMAR1CA1CA2NAMPTALDH1A1 | |
| SCHEMBL7283356 | 0.88 | SIGMAR1 (0.41) | SIGMAR1LTA4HALDH1A1DRD2DRD3 | |
| SCHEMBL7275906 | 0.86 | SIGMAR1 (0.46) | SIGMAR1CACNA1GCA1CA2NAMPT | |
| SCHEMBL7273654 | 0.85 | SIGMAR1 (0.44) | SIGMAR1CA1CA2NAMPTDRD2 | |
| SCHEMBL7275472 | 0.85 | SIGMAR1 (0.41) | SIGMAR1CA1CA2ALDH1A1DRD2 | |
| SCHEMBL7276712 | 0.84 | SIGMAR1 (0.48) | SIGMAR1CACNA1GCA1CA2CYP3A4 | |
| SCHEMBL7304783 | 0.84 | SIGMAR1 (0.39) | SIGMAR1ALDH1A1DRD2DRD3CHRNB4 | |
| SCHEMBL7275050 | 0.83 | SIGMAR1 (0.47) | SIGMAR1CACNA1GCA1CA2NAMPT | |
| SCHEMBL8881851 | 0.83 | SIGMAR1 (0.38) | SIGMAR1LTA4HNAMPTDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |