Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | MMP8 | P22894 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275751 | 1.00 | REN (0.53) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL7276181 | 0.87 | REN (0.51) | REN | |
| SCHEMBL7272851 | 0.87 | REN (0.51) | REN | |
| SCHEMBL10751142 | 0.85 | REN (0.47) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL8481273 | 0.84 | HRH4 (0.47) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL8481278 | 0.84 | HRH4 (0.47) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL10753464 | 0.84 | REN (0.48) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL10422508 | 0.83 | REN (0.52) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL10874442 | 0.82 | REN (0.52) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL7336372 | 0.82 | REN (0.52) | RENHRH4MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992007845-A1 | DERIVATIVES OF AMINO ACIDS AS INHIBITORS OF RENIN, METHODS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-05-14 | — | — | WO | disclosed |
| EP-0483403-A1 | Derivatives of amino acids as inhibitors of renin, methods for their preparation, medicaments containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-05-06 | — | — | EP | disclosed |