Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 4/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 2/20 | 0.38 |
| ▸ | IL1RN | P18510 | 2/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.38 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8481278 | 1.00 | HRH4 (0.47) | HRH4MMP9MMP8MMP2MME | |
| SCHEMBL8481408 | 0.91 | HRH4 (0.56) | HRH4MMP9MMP8MMP2MME | |
| SCHEMBL8481399 | 0.91 | HRH4 (0.56) | HRH4MMP9MMP8MMP2MME | |
| SCHEMBL8481892 | 0.91 | HRH4 (0.56) | HRH4MMP9MMP8MMP2MME | |
| SCHEMBL8481136 | 0.89 | HRH4 (0.49) | HRH4MMP9MMP8MMP2MME | |
| SCHEMBL8481151 | 0.88 | HRH4 (0.48) | HRH4MMP9MMP8MMP2MME | |
| SCHEMBL8484193 | 0.88 | MMP2 (0.55) | HRH4MMP9MMP8MMP2MME | |
| SCHEMBL8484198 | 0.88 | MMP2 (0.55) | HRH4MMP9MMP8MMP2MME | |
| SCHEMBL8481144 | 0.88 | HRH4 (0.48) | HRH4MMP9MMP8MMP2MME | |
| SCHEMBL8485799 | 0.88 | CTSS (0.46) | HRH4MMP9MMP8MMP2MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6008372-A | ANTICARCINOGENIC, ANTIRESTENOSIS AND ANTIPSORIASIS AGENT | WARNER-LAMBERT COMPANY (US) | 1999-12-28 | — | — | US | disclosed |
| WO-1997026246-A1 | SUBSTITUTED HISTIDINE INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1997-07-24 | — | — | WO | disclosed |