Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.56 |
| ▸ | MRGPRX4 | Q96LA9 | 14/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.55 |
| ▸ | RELA | Q04206 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28492714 | 0.82 | GSK3B (0.46) | MRGPRX4TP53NFKB1NFKB2RELA | |
| SCHEMBL5543244 | 0.82 | LOXL2 (0.62) | MRGPRX4SMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL6000790 | 0.82 | MRGPRX4 (0.68) | FOLH1MRGPRX4TP53NFKB1NFKB2 | |
| SCHEMBL11394076 | 0.81 | MAOB (0.39) | — | |
| SCHEMBL13316468 | 0.80 | FOLH1 (0.61) | FOLH1MRGPRX4TP53NFKB1NFKB2 | |
| SCHEMBL5546275 | 0.80 | CYP4F2 (0.59) | TP53SMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL15042306 | 0.79 | AKR1B1 (0.48) | NFKB1HPGD | |
| SCHEMBL13477531 | 0.79 | FOLH1 (0.51) | FOLH1MRGPRX4TP53NFKB1NFKB2 | |
| SCHEMBL565902 | 0.79 | MRGPRX4 (0.67) | FOLH1MRGPRX4TP53NFKB1NFKB2 | |
| SCHEMBL30331845 | 0.79 | FOLH1 (0.59) | FOLH1MRGPRX4TP53NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |