SCHEMBL6000790

SCHEMBL6000790

O=C(O)c1cccc(COCc2cccc(C(=O)O)c2)c1

nearest known ligand 0.68

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 14/20 0.68
ALDH1A1 P00352 1/20 0.65
NPSR1 Q6W5P4 1/20 0.65
FOLH1 Q04609 1/20 0.63
TP53 P04637 3/20 0.61
NFKB1 P19838 3/20 0.61
NFKB2 Q00653 3/20 0.61
RELA Q04206 3/20 0.61
SMN1; SMN2 Q16637 3/20 0.61
PKM P14618 2/20 0.61
RAB9A P51151 2/20 0.61
RXFP1 Q9HBX9 1/20 0.61
MEN1 O00255 1/20 0.59
NPC1 O15118 1/20 0.59
MITF O75030 1/20 0.59
HPGD P15428 1/20 0.59
XBP1 P17861 1/20 0.59
KMT2A Q03164 1/20 0.59
NR4A2 P43354 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27650204 0.96 NR4A2 (0.65) MRGPRX4ALDH1A1NPSR1FOLH1TP53
SCHEMBL3315985 0.89 MRGPRX4 (0.68) MRGPRX4ALDH1A1NPSR1FOLH1TP53
SCHEMBL10653127 0.89 ALDH1A1 (0.62) MRGPRX4ALDH1A1NPSR1FOLH1TP53
SCHEMBL19301712 0.88 MRGPRX4 (0.58) MRGPRX4ALDH1A1NPSR1FOLH1TP53
SCHEMBL11427053 0.88 ALDH1A1 (0.57) MRGPRX4ALDH1A1NPSR1FOLH1TP53
SCHEMBL13316468 0.86 FOLH1 (0.61) MRGPRX4FOLH1TP53NFKB1NFKB2
SCHEMBL3312463 0.86 MRGPRX4 (0.60) MRGPRX4ALDH1A1NPSR1FOLH1TP53
SCHEMBL21533298 0.85 ALDH1A1 (0.55) MRGPRX4ALDH1A1NPSR1FOLH1TP53
SCHEMBL3316017 0.85 ALDH1A1 (0.55) MRGPRX4ALDH1A1NPSR1FOLH1TP53
SCHEMBL28277763 0.85 MRGPRX4 (0.58) MRGPRX4ALDH1A1NPSR1FOLH1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2590656-B1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX INC (US) 2017-11-15 EP disclosed
US-20170037010-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. 2017-02-09 US disclosed
US-20170037010-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. 2017-02-09 US disclosed
EP-2591354-B1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX INC (US) 2016-09-07 EP disclosed
US-9301951-B2 Compounds and methods for inhibiting phosphate transport ARDELYX, INC. (US) 2016-04-05 US disclosed
US-9301951-B2 Compounds and methods for inhibiting phosphate transport ARDELYX, INC. (US) 2016-04-05 US disclosed
US-20150164876-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. 2015-06-18 US disclosed
US-20150164876-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. 2015-06-18 US disclosed
US-8916569-B2 Compounds and methods for inhibiting phosphate transport ARDELYX, INC. (US) 2014-12-23 US disclosed
US-8916569-B2 Compounds and methods for inhibiting phosphate transport ARDELYX, INC. (US) 2014-12-23 US disclosed
US-20140023611-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. 2014-01-23 US disclosed
US-20140023611-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. 2014-01-23 US disclosed
WO-2012054110-A2 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. (US) 2012-04-26 WO disclosed
WO-2012006475-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. (US) 2012-01-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150164876-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT SLC34A2, SLC34A1, SLC10A2 MRGPRX4 947/4885ALDH1A1 2892/4885NPSR1 818/4885
US-20170037010-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT SLC34A2, SLC34A1, SLC10A2 MRGPRX4 947/4885ALDH1A1 2892/4885NPSR1 818/4885
US-20140023611-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT SLC10A2, SLC34A2, SLC34A3 MRGPRX4 2362/4885ALDH1A1 3332/4885NPSR1 2263/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.