Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9402417 | 0.84 | GRM4 (0.43) | MAPTHTTALDH1A1TRIM24TRIM33 | |
| SCHEMBL10678813 | 0.84 | MAPK14 (0.46) | MAPTHTTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL10682704 | 0.83 | ERN1 (0.43) | MAPTHTTKDM4ETRIM24TRIM33 | |
| SCHEMBL7280127 | 0.82 | TRIM24 (0.40) | MAPTHTTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7357810 | 0.78 | ERN1 (0.47) | ALDH1A1SMN1; SMN2MAPK10TRIM24TRIM33 | |
| SCHEMBL30754775 | 0.77 | MAPT (0.58) | MAPTHTTALDH1A1SMN1; SMN2LRRK2 | |
| SCHEMBL1376342 | 0.77 | DHODH (0.56) | MAPTHTTALDH1A1SMN1; SMN2TRIM24 | |
| SCHEMBL9402324 | 0.76 | DHODH (0.57) | MAPTSMN1; SMN2MAPK10TRIM24TRIM33 | |
| SCHEMBL16627420 | 0.76 | ALDH1A1 (0.44) | MAPTHTTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL11095322 | 0.76 | MAPT (0.43) | MAPTHTTALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5214055-A | Analgesics, psychological disorders, anxiolytic agents | ADIR ET COMPAGNIE (FR) | 1993-05-25 | — | — | US | disclosed |
| US-5189045-A | Antiserotonine agent | ADIR ET COMPAGNIE (FR) | 1993-02-23 | — | — | US | disclosed |
| US-5134147-A | Antipsychotic agents | ADIR ET COMPAGNIE (FR) | 1992-07-28 | — | — | US | disclosed |
| US-5100902-A | Dopamine and Serotonin Antagonists, Antipsychotic Agents | ADIR ET COMPAGNIE (FR) | 1992-03-31 | — | — | US | disclosed |
| EP-0457686-A1 | Novel aminopiperidine, aminopyrrolidine and aminoperhydroazepine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-11-21 | — | — | EP | disclosed |
| US-4786642-A | ANTIULCER | SOCIETE ANONYME: CARPIBEM (FR) | 1988-11-22 | — | — | US | disclosed |