Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 4/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6937389 | 0.82 | SSTR4 (0.43) | SSTR4KCNH2 | |
| SCHEMBL21484361 | 0.82 | SSTR4 (0.41) | SSTR4 | |
| SCHEMBL5948132 | 0.82 | SSTR4 (0.41) | SSTR4 | |
| SCHEMBL8292968 | 0.81 | SSTR4 (0.45) | SSTR4 | |
| SCHEMBL3742282 | 0.81 | SSTR4 (0.45) | SSTR4 | |
| Hydrochloric Acid SCHEMBL4031709 | 0.80 | SSTR4 (0.44) | SSTR4 | |
| SCHEMBL1662913 | 0.79 | ALDH1A1 (0.40) | SSTR4 | |
| SCHEMBL23303999 | 0.79 | CHRNB2 (0.42) | SSTR4KCNH2 | |
| SCHEMBL3787216 | 0.79 | SSTR4 (0.38) | CTSCSSTR4 | |
| SCHEMBL6798494 | 0.78 | HPGD (0.42) | SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265381-B1 | MORPHOLINOUREA AND RELATED DERIVATIVES OF PENTAFLUOROETHYL PEPTIDES | MERRELL PHARMACEUTICALS, INC. | 2001-07-24 | — | — | US | disclosed |
| US-5714470-A | PENTAFLUORO ALKYL TERMINATED PEPTIDE DERIVATIVES; TREATMENT OF INFLAMMATORY DISEASES, EMPHYSEMA AND CHRONIC BRONCHITIS | MERRELL PHARMACEUTICALS, INC. (US) | 1998-02-03 | — | — | US | disclosed |
| EP-0529568-B1 | Novel orally-active elastase inhibitors | MERRELL PHARMA INC (US) | 1997-01-15 | — | — | EP | disclosed |
| US-5478811-A | Antiinflammatory agents, enzyme inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-12-26 | — | — | US | disclosed |
| EP-0529568-A1 | Novel orally-active elastase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1993-03-03 | — | — | EP | disclosed |