Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 2/20 | 0.38 |
| ▸ | CTSC | P53634 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3742282 | 0.84 | SSTR4 (0.45) | SSTR4 | |
| SCHEMBL8292968 | 0.84 | SSTR4 (0.45) | SSTR4 | |
| Hydrochloric Acid SCHEMBL4031709 | 0.83 | SSTR4 (0.44) | SSTR4 | |
| SCHEMBL6015068 | 0.81 | SSTR4 (0.37) | SSTR4CTSC | |
| SCHEMBL23303999 | 0.81 | CHRNB2 (0.42) | SSTR4 | |
| SCHEMBL6937389 | 0.81 | SSTR4 (0.43) | SSTR4 | |
| SCHEMBL21484361 | 0.81 | SSTR4 (0.41) | SSTR4 | |
| SCHEMBL5948132 | 0.81 | SSTR4 (0.41) | SSTR4 | |
| SCHEMBL7276192 | 0.79 | CTSC (0.41) | SSTR4CTSC | |
| SCHEMBL1662913 | 0.79 | ALDH1A1 (0.40) | SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016004272-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2016-01-07 | — | — | WO | claimed |
| US-20160002225-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | SCHRODINGER, LLC | 2016-01-07 | — | — | US | claimed |
| EP-2252617-A1 | 6-ARYL-IMIDAZ0[L, 2-A]PYRAZINE DERIVATIVES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI Pharmaceuticals, Inc. (US) | 2010-11-24 | — | — | EP | claimed |
| US-20090221612-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | Kronos Bio, Inc. | 2009-09-03 | — | — | US | claimed |
| WO-2009102468-A1 | 6-ARYL-IMIDAZ0[L, 2-A] PYRAZINE DERIVATIVES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | claimed |
| US-9580416-B2 | Inhibitors of Bruton's tyrosine kinase | PHARMACYCLICS LLC (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160002225-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | SCHRODINGER, LLC | 2016-01-07 | — | — | US | disclosed |
| US-8697699-B2 | Imidazopyrazine SYK inhibitors | GILEAD CONNECTICUT, INC. (US) | 2014-04-15 | — | — | US | disclosed |
| US-20130023499-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | GILEAD CONNECTICUT, INC. (US) | 2013-01-24 | — | — | US | disclosed |
| EP-2252617-A1 | 6-ARYL-IMIDAZ0[L, 2-A]PYRAZINE DERIVATIVES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI Pharmaceuticals, Inc. (US) | 2010-11-24 | — | — | EP | disclosed |
| US-20090221612-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | Kronos Bio, Inc. | 2009-09-03 | — | — | US | disclosed |
| WO-2009102468-A1 | 6-ARYL-IMIDAZ0[L, 2-A] PYRAZINE DERIVATIVES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |
| US-20090054467-A1 | Pyrrolo Pyrimidines as Agents for the Inhibition of Cystein Proteases | BETSCHART CLAUDIA | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002225-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LYN, LCK | SSTR4 4773/4885CTSC 1872/4885DRD2 3983/4885 |
| US-20130023499-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | SYK, MYD88, BTK | SSTR4 2580/4885CTSC 2559/4885DRD2 3996/4885 |
| US-20090054467-A1 | Pyrrolo Pyrimidines as Agents for the Inhibition of Cystein Proteases | CTSK, CTSS, CTSZ | SSTR4 3698/4885CTSC 20/4885DRD2 4870/4885 |
| US-20090221612-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | SYK, MYD88, BTK | SSTR4 2580/4885CTSC 2559/4885DRD2 3996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.