Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7267304 | 0.83 | CYP3A4 (0.40) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| SCHEMBL9597563 | 0.83 | KCNH2 (0.52) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| SCHEMBL7277715 | 0.79 | CYP3A4 (0.35) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| SCHEMBL7276297 | 0.78 | HTR6 (0.33) | CYP3A4CYP1A2CYP2D6SMN1; SMN2HTR6 | |
| Fabesetron SCHEMBL1021975 | 0.75 | HTR3A (0.47) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Fabesetron SCHEMBL1350066 | 0.75 | HTR3A (0.47) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Fabesetron SCHEMBL30949355 | 0.75 | HTR3A (0.47) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Fabesetron SCHEMBL1026223 | 0.75 | CASP6 (0.48) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| Fabesetron SCHEMBL2232218 | 0.75 | CASP6 (0.48) | CYP3A4KCNH2CYP1A2CYP2D6HTR3E | |
| SCHEMBL7276214 | 0.75 | TSHR (0.35) | CYP3A4SMN1; SMN2TSHRKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0451538-B1 | Use of pyridoindole derivatives in the treatment of ischemic disorders | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-05-22 | — | — | EP | disclosed |
| EP-0361317-B1 | Pyridoindole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-04-05 | — | — | EP | disclosed |
| US-5290785-A | Therapeutic agent for ischemic diseases | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-03-01 | — | — | US | disclosed |
| US-5173493-A | For treatment or prevention of nausea or vomiting | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-12-22 | — | — | US | disclosed |
| US-5141945-A | 5-Hydroxytryptamine antagonists, treatment or prevention of nausea and vomiting | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-08-25 | — | — | US | disclosed |
| EP-0451538-A2 | Use of pyridoindole derivatives in the treatment of ischemic disorders | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-10-16 | — | — | EP | disclosed |
| EP-0361317-A2 | Pyridoindole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-04-04 | — | — | EP | disclosed |