SCHEMBL7276386

SCHEMBL7276386

COC(=O)C[C@@H]1C[C@@H](COc2ccc(-c3ccc(C(=N)N)nc3)cc2)NC1=O

nearest known ligand 0.61

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 1/20 0.61
ITGA2B P08514 1/20 0.61
NAAA Q02083 3/20 0.37
IRAK4 Q9NWZ3 15/20 0.35
PDE10A Q9Y233 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7275202 0.90 ITGB3 (0.62) ITGB3ITGA2BIRAK4
SCHEMBL7275264 0.90 ITGB3 (0.76) ITGB3ITGA2BNAAAIRAK4
Hydrochloric Acid SCHEMBL7275160 0.89 ITGB3 (0.58) ITGB3ITGA2BNAAAIRAK4
SCHEMBL7275647 0.89 ITGB3 (0.52) ITGB3ITGA2BNAAAIRAK4PDE10A
Hydrochloric Acid SCHEMBL7284278 0.88 ITGB3 (0.56) ITGB3ITGA2BNAAAIRAK4PDE10A
Hydrochloric Acid SCHEMBL7278520 0.88 ITGB3 (0.56) ITGB3ITGA2BNAAAIRAK4PDE10A
SCHEMBL7274479 0.88 ITGB3 (0.79) ITGB3ITGA2B
Hydrochloric Acid SCHEMBL7282648 0.87 ITGB3 (0.78) ITGB3ITGA2B
Hydrochloric Acid SCHEMBL7284242 0.87 ITGB3 (0.78) ITGB3ITGA2B
Hydrochloric Acid SCHEMBL7275325 0.86 ITGB3 (0.56) ITGB3ITGA2BIRAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0528369-B1 Cyclic imino derivatives, pharmaceutical compositions containing them and process for their preparation BOEHRINGER INGELHEIM PHARMA (DE) 1999-11-24 EP disclosed
US-5455348-A Anticoagulants Thomae, Karl (DE) 1995-10-03 US disclosed
EP-0528369-A2 Cyclic imino derivatives, pharmaceutical compositions containing them and process for their preparation Dr. Karl Thomae GmbH (DE) 1993-02-24 EP disclosed