Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.56 |
| ▸ | HTR3B | O95264 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.56 |
| ▸ | HTR3A | P46098 | 1/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7278311 | 1.00 | HTR3E (0.56) | HTR3EHTR3BALOX15TSHRCHRNA7 | |
| SCHEMBL1160143 | 0.81 | — | — | |
| SCHEMBL9443124 | 0.81 | — | — | |
| SCHEMBL1159851 | 0.81 | — | — | |
| SCHEMBL7326360 | 0.80 | HTR3A (0.61) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7270865 | 0.80 | — | — | |
| SCHEMBL9443039 | 0.78 | HTR3A (0.53) | HTR3A | |
| SCHEMBL7278139 | 0.78 | HTR3A (0.53) | HTR3A | |
| SCHEMBL7270771 | 0.78 | HTR3A (0.53) | HTR3A | |
| SCHEMBL7330460 | 0.78 | HTR3A (0.61) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430190-B1 | New tricyclic compounds | SYNTEX INC (US) | 1995-07-05 | — | — | EP | disclosed |
| US-5202333-A | Tricyclic 5-HT3 receptor antagonists | SYNTEX (U.S.A.) INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0430190-A2 | New tricyclic compounds | SYNTEX (U.S.A.) INC. (US) | 1991-06-05 | — | — | EP | disclosed |