Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 4/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7285956 | 0.83 | TSHR (0.38) | SIGMAR1PREPELANESLC15A1FKBP1A | |
| SCHEMBL9745927 | 0.83 | PREP (0.39) | SIGMAR1PREPELANESLC15A1FKBP1A | |
| SCHEMBL7279078 | 0.83 | PREP (0.39) | SIGMAR1PREPELANESLC15A1FKBP1A | |
| Hydrochloric Acid SCHEMBL7287636 | 0.80 | ACE (0.35) | SIGMAR1PREPELANEACECCR5 | |
| SCHEMBL7286288 | 0.79 | FAAH (0.39) | SIGMAR1PREPELANEFKBP1AACE2 | |
| SCHEMBL7278813 | 0.79 | F2 (0.37) | SIGMAR1PREPELANEFKBP1AACE2 | |
| SCHEMBL7279371 | 0.78 | FAAH (0.34) | SIGMAR1PREPELANESLC15A1FKBP1A | |
| SCHEMBL7279122 | 0.78 | F2 (0.37) | PREPCASP1 | |
| SCHEMBL7279611 | 0.77 | ELANE (0.34) | SIGMAR1PREPELANECCR5 | |
| SCHEMBL6449506 | 0.77 | PREP (0.35) | SIGMAR1PREPELANEFKBP1AACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291234-B1 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5164371-A | HETEROCYCLIC KETONES | ICI AMERICAS INC. (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0291234-A2 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC. (US) | 1988-11-17 | — | — | EP | disclosed |