Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 7/20 | 0.39 |
| ▸ | PREP | P48147 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7278813 | 0.85 | F2 (0.37) | PREPSIGMAR1FKBP1AELANEACE2 | |
| SCHEMBL7279371 | 0.84 | FAAH (0.34) | FAAHPREPSIGMAR1FKBP1AELANE | |
| SCHEMBL7276163 | 0.82 | ELANE (0.39) | PREPELANE | |
| SCHEMBL6449506 | 0.81 | PREP (0.35) | PREPSIGMAR1FKBP1AELANEACE2 | |
| SCHEMBL7004719 | 0.81 | NPC1 (0.37) | PREPFKBP1AELANELMNA | |
| SCHEMBL7279122 | 0.81 | F2 (0.37) | PREPLMNAHSD17B10 | |
| SCHEMBL9744946 | 0.80 | ELANE (0.47) | ELANE | |
| SCHEMBL7289208 | 0.80 | ELANE (0.47) | ELANE | |
| SCHEMBL7276586 | 0.79 | SIGMAR1 (0.39) | PREPSIGMAR1FKBP1AELANEACE2 | |
| SCHEMBL7288778 | 0.78 | ELANE (0.34) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291234-B1 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5164371-A | HETEROCYCLIC KETONES | ICI AMERICAS INC. (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0291234-A2 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC. (US) | 1988-11-17 | — | — | EP | disclosed |