Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 13/20 | 0.49 |
| ▸ | CTRC | Q99895 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284545 | 0.88 | HDAC3 (0.52) | HDAC3HDAC1HDAC2ELANECTRC | |
| SCHEMBL7274678 | 0.85 | HDAC3 (0.49) | HDAC3HDAC1HDAC2ELANECTRC | |
| SCHEMBL7276488 | 0.85 | ELANE (0.64) | ELANECTRCCASP1 | |
| SCHEMBL6556446 | 0.83 | ELANE (0.69) | HDAC3HDAC1HDAC2ELANE | |
| SCHEMBL7284774 | 0.81 | ELANE (0.60) | ELANECTRC | |
| SCHEMBL21685578 | 0.81 | NPC1 (0.50) | ELANECTRCCASP1 | |
| SCHEMBL8536815 | 0.80 | ELANE (0.67) | ELANECTRCCASP1 | |
| SCHEMBL8536676 | 0.80 | ELANE (0.59) | APEX1ELANECTRCKDM4EALDH1A1 | |
| SCHEMBL7283124 | 0.79 | ELANE (0.49) | ELANECTRCCASP1 | |
| SCHEMBL2798490 | 0.79 | ELANE (0.64) | ELANECTRCCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |